Arming symbionts with antimalarials

Arming Cloud Services with Task Aspects

Our cloud services are losing too many battles to faults like software bugs, resource interference, and hardware failures. Many tools can help us win these battles: model checkers to verify, fault injection to find bugs, replay to debug, and many more. Unfortunately, tools are currently afterthoughts in cloud service designs that must either be tediously tangled into service implementations or ...

Arming NK cells with enhanced antitumor activity

Natural killer (NK) cells hold great promise for adoptive cancer immunotherapy. The antitumor activity of NK cells can be enhanced by the transgene driven expression of chimeric antigen receptors that facilitate the selective recognition and killing of malignant cells. Recent data from our laboratory suggest that NK cells may similarly be "armed" against neoplastic cells by the expression of ca...

Arming antitumor T cells

The immune system can only prevent cancer if it recognizes and destroys precancerous cells. Antigenic targets of such an early immune response, however, have been elusive. Spisek et al. (page 831) now find that an embryonic stem cell marker is a bull's eye for immune cells in patients who have precancerous lesions but never develop multiple myeloma. Multiple myeloma is an incurable cancer that ...

Synthetic Antimalarials

Marine Antimalarials

Malaria is an infectious disease causing at least 1 million deaths per year, and, unfortunately, the chemical entities available to treat malaria are still too limited. In this review we highlight the contribution of marine chemistry in the field of antimalarial research by reporting the most important results obtained until the beginning of 2009, with particular emphasis on recent discoveries....